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Nigericin sodium salt, 98+%

Product Code. 15403959
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10 mg
Unit Size:
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Product Code. 15403959 Supplier Thermo Scientific Alfa Aesar Supplier No. J61349.MA
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Description

A potassium ionophore | CAS: 28643-80-3 | C40H68O11 | 724.973 g/mol

Nigericin sodium salt is a polyether ionophore which catalyzes the electroneutral exchange of alkali metal (K+) for H+ (antiport). It disrupts membrane potential and stimulates ATPase activity in mitochondria. It transports monovalent cations across membranes with the following specificity: K+ >Rb+ >Cs+ >>Na. It kills bacteria by facilitating the diffusion of ions across membranes. It is widely used in studies of the consequences of changes in membrane potential in variable systems.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Nigericin sodium salt is a polyether ionophore which catalyzes the electroneutral exchange of alkali metal (K+) for H+ (antiport). It disrupts membrane potential and stimulates ATPase activity in mitochondria. It transports monovalent cations across membranes with the following specificity: K+ >Rb+ >Cs+ >>Na. It kills bacteria by facilitating the diffusion of ions across membranes. It is widely used in studies of the consequences of changes in membrane potential in variable systems.

Solubility
Soluble in chloroform, methanol or ethanol

Notes
Stable under recommended storage conditions. Incompatible with oxidizing agents, acids, bases and heat.
TRUSTED_SUSTAINABILITY

Specifications

CAS 28643-80-3
Color White
Molecular Formula C40H68O11
MDL Number MFCD00036825
Quantity 10 mg
UN Number UN3462
Beilstein 3892398
Merck Index 14,6541
Synonym nigericin
Solubility Information Soluble in chloroform, methanol or ethanol
InChI Key DANUORFCFTYTSZ-FBMOGUJMSA-N
SMILES CC1CCC(OC1C(C)C(=O)O)CC2CC(C(C3(O2)C(CC(O3)(C)C4CCC(O4)(C)C5C(CC(O5)C6C(CC(C(O6)(CO)O)C)C)C)C)C)OC
IUPAC Name (2R)-2-[(2R,3S,6R)-6-[[(2S,4R,5R,6R,7R,9R)-2-[(2R,5S)-5-[(3S,5R)-5-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]-3-methyloxolan-2-yl]-5-methyloxolan-2-yl]-7-methoxy-2,4,6-trimethyl-1,10-dioxaspiro[4.5]decan-9-yl]methyl]-3-methyloxan-2-
Molecular Weight (g/mol) 724.973
PubChem CID 123134611
Formula Weight 746.94
Percent Purity ≥98%
Physical Form Powder
Chemical Name or Material Nigericin sodium salt
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Safety and Handling

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Product Identifier
  • Nigericin sodium salt
 Signal Word
  • Danger
 Hazard Category
  • Acute toxicity Category 3
  • Serious eye damage/eye irritation Category 2
  • Skin corrosion/irritation Category 2
  • Specific target organ toxicity Category 3
 Hazard Statement
  • H301-Toxic if swallowed.
  • H315-Causes skin irritation.
  • H319-Causes serious eye irritation.
  • H335-May cause respiratory irritation.
 Precautionary Statement
  • P280-Wear protective gloves/protective clothing/eye protection/face protection.
  • P301+P310-IF SWALLOWED: Immediately call a POISON CENTER/doctor /
  • P302+P352-IF ON SKIN: Wash with plenty of water/soap.
  • P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
  • P332+P313-If skin irritation occurs: Get medical advice/attention.
  • P337+P313-If eye irritation persists: Get medical advice/attention.
 Supplemental information
  • MIXTURE LIST-Contain: Nigericin sodium salt
SDS

RUO – Research Use Only

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