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  5. Tocris Bioscience™ NIBR LTSi

Tocris Bioscience™ NIBR LTSi

Product Code. 30226373
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50 mg
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30226374 50 mg 50mg
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Product Code. 30226373 Supplier Tocris Bioscience™ Supplier No. 8175/10

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Description

Potent and selective LATS inhibitor; activates YAP signaling

NIBR-LTSi is a potent and selective large tumor suppressor kinase (LATS) inhibitor (IC50 = 1.4 nM). Also activates YAP signaling (EC50 = 1.0 - 2.7 μM). Promotes liver organoid formation (EC50 = 0.35 μM), hepatocyte proliferation, ISC expansion, and blocks differentiation. NIBR-LTSi is orally bioavailable and suitable for use in vivo and in vitro.
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Specifications

Chemical Name or Material N-[4-[(3R)-Piperidin-3-yl]oxyphenyl]-1H-pyrrolo[2,3-b]pyridin-4-amine
Quantity 10 mg
Target Other Kinase Inhibitors
Molecular Formula C18H20N4O
Purity 0.98
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