missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Protein Analysis Reagents
  4. Bioactive Small Molecules
  5. R&D Systems™ LTGO-33

R&D Systems™ LTGO-33

Product Code. 31927904
Change view
Click to view available options
Quantity:
10 mg
50 mg
Unit Size:
10mg
50mg
2 product options available for selection
Product selection table with 2 available options. Use arrow keys to navigate and Enter or Space to select.
Product Code. Quantity Unit Size
31927904 50 mg 50mg
31927901 10 mg 10mg
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 2 options available.
2 options
This item is not returnable. View return policy
Product Code. 31927904 Supplier R&D Systems™ Supplier No. 8865/50
 Restricted Item
Estimated Shipment: 03-11-2026
Add to basket
Add to basket

missing translation for 'validMainframeMsg'

This item is not returnable. View return policy

Description

A Tocris product, part of R&D Systems. Potent and selective state-independent inhibitor of NaV1.8 sodium channels

LTGO-33 is a potent and selective state-independent inhibitor of NaV1.8 sodium channels (IC50 = 13 nM for the closed state; IC50 = 24 nM for the inactive state). It displays 600-fold selectivity over other sodium channels such as NaV1.1-1.7 and NaV1.9. By binding to NaV1.8 channels, LTGO-33 inhibits action potential initiation and transmission of pain signals in human DRG neurons. Unlike other NaV1.8 inhibitors that preferentially interact with an inactivated state via the pore region, LTGO-33 is state-independent with similar potencies against closed and inactivated channels.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material (R)-2-(4-Fluoro-2-methylphenoxy)-N-(3-(S-methylsulfonimidoyl)phenyl)-5-(trifluoromethyl)nicotinamide
CAS 2834106-06-6
Quantity 50 mg
Product Line Tocris
Target Voltage-gated Sodium Channel Inhibitors
Molecular Formula C21H17F4N3O3S
Purity 98%
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.