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R&D Systems™ L-685,458

Product Code. 18045312
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1 mg
Unit Size:
1mg
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Product Code. Quantity Unit Size
18045312 1 mg 1mg
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Product Code. 18045312 Supplier R&D Systems™ Supplier No. 2627/1
  • ONLINE EXCLUSIVE PRICE
    430.00€
    406.35€ / 1mg
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Estimated Shipment: 29-10-2026
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Description

A Tocris product, part of R&D Systems. Potent and selective γ-secretase inhibitor

Potent and selective γ-secretase inhibitor (IC50 = 17 nM) that displays > 50-fold selectivity over a range of aspartyl, serine and cysteine proteases. Exhibits equal potency for inhibition of Aβ40 and Aβ42 peptides (IC50 values are 48 and 67 nM respectively in human neuroblastoma cells). Also regulates CXCR4 and VEGFR2 expression through inhibition of Notch signaling in vitro.
TRUSTED_SUSTAINABILITY

Specifications

CAS 292632-98-5
Quantity 1 mg
Product Line Tocris
Molecular Formula C39H52N4O6
Formula Weight 672.85
Purity >97%
Molecular Weight (g/mol) 672.867
Chemical Name or Material L-685, 458
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