missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Protein Analysis Reagents
  4. Bioactive Small Molecules
  5. Tocris Bioscience™ L-168,049

Tocris Bioscience™ L-168,049
GREENER_CHOICE

Product Code. 30000708
Click to view available options
Quantity:
10 mg
50 mg
Unit Size:
10mg
50mg
This item is not returnable. View return policy

Product Code. 30000708

Brand: Tocris Bioscience™ 2311/10

Please to purchase this item. Need a web account? Register with us today!

This item is not returnable. View return policy

Description

Potent, orally active human glucagon receptor antagonist

Very potent and selective, non-competitive antagonist of the human glucagon receptor (hGR). Binds with high affinity to human GR (IC50 = 3.7 nM), and moderate affinity to murine and canine GRs (IC50 values are 63 and 60 nM respectively). In contrast, displays poor affinity for rat, guinea pig, and rabbit glucagon receptors (IC50 > 1 μM). In functional studies, inhibits glucagon-stimulated cAMP synthesis in CHO cells expressing hGR (IC50 = 41 nM), and in murine liver membranes. Orally active in vivo.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 191034-25-0
Molecular Formula C24H20BrClN2O

Specifications

Quantity 10 mg
Formula Weight 467.79
Purity >99%
Molecular Weight (g/mol) 467.791
Chemical Name or Material L-168, 049
Product Content Correction

Your input is important to us. Please complete this form to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Thank You! Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.