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  5. STEMCELL Technologies JAK Inhibitor I

STEMCELL Technologies JAK Inhibitor I

Product Code. 17130312
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Quantity:
1 mg
Unit Size:
1mg
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Product Code. 17130312

Brand: STEMCELL Technologies 74024

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This item is not returnable. View return policy

Description

JAK/STAT pathway inhibitor; Inhibits JAK1, JAK2, and JAK3

  • Janus Associated Kinase (JAK) Inhibitor I is a pyridine-containing tetracycle that disrupts JAK activity by interacting with the ATP binding domain
  • This inhibitor inhibits mouse JAK3 with Ki = 5 nM, JAK family members TYK2 and JAK2 with IC50 = 1 nM, and mouse JAK1 with IC50 = 15 nM, while showing weaker inhibition of other kinases (Thompson et al.)
  • Inhibits the generation of mouse induced pluripotent stem cells (Efe et al.; Kim et al.)
  • Inhibits anti-viral response associated with JAK/STAT pathway activation (Xu et al.)

Specifications

CAS 457081-03-7
Synonym CMP 6; Janus-associated kinase inhibitor I;Pyridone 6
Quantity 1 mg
Molecular Formula C18H16FN3O
Purity ≥98%
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