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DiscoverX InCELL Hunter™ HEK 293 RIPK2 Kinase Binding Cell Line

Product Code. 17354799
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Quantity:
2 Vials
Unit Size:
2 ampoules
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17354799 2 Vials 2 ampoules
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Product Code. 17354799 Supplier DiscoverX Supplier No. 960050C1

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Description

The InCELL Hunter™ HEK 293 RIPK2 Kinase Binding Cell Line measures target engagement via compound-induced stabilization of RIPK2 target protein. This cell line ships as two vials of cryopreserved cells.

The InCELL Hunter™ HEK 293 RIPK2 Kinase Binding Cell Line is a stable, engineered cell line for use in studying small molecule drug candidates that engage with kinases. This cell line enables assessment of compound-engagement-based stabilization of RIPK2 via detection of RIPK2 levels. This product uses EFC technology. The cell line included overexpresses RIPK2 target protein fused to PL. In the absence of compound that binds and stabilizes the target, this protein is denatured by the heat treatment and no EFC signal is produced. When compound engages and heat-stabilizes the target, EA contained in the detection reagent produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells.

Specifications

Assay Entry Target Engagement
Cell Line 293H
For Use With (Application) Cell Lines
Primary Agonist Foretinib (GSK1363089)
Quantity 2 Vials
Target Entry RIPK2
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