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ACROBiosystems Human IL-2 R alpha / CD25 Protein, Fc Tag

HPLC-verified

Brand:  ACROBiosystems ILA-H5251-1MG

Additional Details : Weight : 0.00001kg

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Product Code. 15817077

  • 1614.07€ / 1mg


Estimated Shipment: 25-10-2021
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Description

Description

Interleukin-2 receptor subunit alpha (IL2RA) is also known as IL-2R subunit alpha, IL-2-RA, IL2-RA, TAC antigen, p55, CD antigen CD25, is a type I transmembrane glycoprotein. IL2RA is expressed on activated T cells and regulatory T cells, and is capable of binding IL2 with low affinity by itself. However, a ligand-induced high affinity heterotrimeric receptor complex is produced when IL2RA is associated non-covelently with the IL2 receptor beta and gamma chain, and subsequently initiates the intacellular signal pathways such as MAPK or JAK/STAT. On dendritic cells (DC), CD25 has been previously regarded as an activation marker, while both murine and human DC can express CD25, they do not express the beta-chain of the IL-2 receptor, which is indispensable for the execution of IL-2 signaling.

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 48.4 kDa. The protein migrates as 60-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Specifications

Specifications

NP_000408
HEK293
Human
48.4 kDa
1 mg
Glu 22 - Cys 213
IL2RA,CD25,p55,IL2-RA,IL-2-RA
Unconjugated
Tris with Glycine, Arginine and NaCl, pH7.5
Less than 1.0 EU / µg by the LAL method.
Bio-Markers and CD Antigens
Powder
>95% as determined by SDS-PAGE
Human IL-2 R alpha Protein, Fc Tag (HPLC-verified) (ILA-H5251) is expressed from human 293 cells (HEK293). It contains AA Glu 22 - Cys 213 (Accession # NP_000408).
-20°C
IL-2 R alpha
Fc Tag
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