missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Protein Analysis Reagents
  4. Bioactive Small Molecules
  5. STEMCELL Technologies GW2580

STEMCELL Technologies GW2580

Product Code. 17130072
Encompass_Preferred
Click to view available options
Quantity:
5 mg
25 mg
Unit Size:
25mg
5mg
This item is not returnable. View return policy

Product Code. 17130072

Brand: STEMCELL Technologies 72472

Please to purchase this item. Need a web account? Register with us today!

This item is not returnable. View return policy

Description

CSF-1 pathway inhibitor; Inhibits cFMS

  • GW2580 is a selective inhibitor of cFMS kinase (IC50 = 0.03 μM) (Conway et al.), 2008), blocking its ability to autophosphorylate colony-stimulating factor (CSF-1 or M-CSF), which promotes the survival, proliferation, and differentiation of macrophages
  • Demonstrates the importance of CSF-1 in promoting myeloid lineage bias in mouse hematopoietic stem cells (Mossadegh-Keller et al.)
  • Demonstrates the importance of CSF-1 in expansion of mouse and human macrophage colonies and monocytes (He et al.; Clanchy et al.; Conway et al.), 2008; Conway et al.), 2005)
  • Inhibits bone degradation in cultures of human osteoclasts, rat calvaria, and rat fetal long bone (Conway et al.), 2005), and in mouse models of arthritis (Conway et al.), 2008)

Specifications

CAS 870483-87-7
Quantity 5 mg
Molecular Formula C20H22N4O3
Purity ≥98%
Product Content Correction

The Fisher Scientific Encompass Program offers items which are not part of our distribution portfolio. These products typically do not have pictures or detailed descriptions. However, we are committed to improving your shopping experience. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Thank You! Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.