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STEMCELL Technologies GW2580

Product Code. 17130072
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5 mg
25 mg
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25mg
5mg
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17130072 5 mg 5mg
17140072 25 mg 25mg
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Product Code. 17130072 Supplier STEMCELL Technologies Supplier No. 72472

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Description

CSF-1 pathway inhibitor; Inhibits cFMS

  • GW2580 is a selective inhibitor of cFMS kinase (IC50 = 0.03 μM) (Conway et al.), 2008), blocking its ability to autophosphorylate colony-stimulating factor (CSF-1 or M-CSF), which promotes the survival, proliferation, and differentiation of macrophages
  • Demonstrates the importance of CSF-1 in promoting myeloid lineage bias in mouse hematopoietic stem cells (Mossadegh-Keller et al.)
  • Demonstrates the importance of CSF-1 in expansion of mouse and human macrophage colonies and monocytes (He et al.; Clanchy et al.; Conway et al.), 2008; Conway et al.), 2005)
  • Inhibits bone degradation in cultures of human osteoclasts, rat calvaria, and rat fetal long bone (Conway et al.), 2005), and in mouse models of arthritis (Conway et al.), 2008)

Specifications

CAS 870483-87-7
Quantity 5 mg
Molecular Formula C20H22N4O3
Purity ≥98%
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