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  6. Thermo Scientific™ EZ-Link™ TFP Ester-PEG4-DBCO

Thermo Scientific™ EZ-Link™ TFP Ester-PEG4-DBCO

Product Code. p-9597000 Shop All Thermo Scientific Products
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Quantity:
10 x 1 mg
Unit Size:
Pack of 10
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Product Code. 17621586

Brand: Thermo Scientific™ C20043

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Description

An amine reactive heterobifunctional crosslinker which contains a dibenzylcyclooctyne (DBCO) group for copper-free click chemistry applications. The crosslinker can be used to label a variety of amine containing molecules such as proteins, biomolecules, or small molecules.

  • An amine reactive heterobifunctional crosslinker which contains a dibenzylcyclooctyne (DBCO) group for copper-free click chemistry applications
  • The crosslinker can be used to label a variety of amine containing molecules such as proteins, biomolecules, or small molecules
  • Once a protein or (bio)molecule is DBCO labeled, it can undergo a copper-free azide-alkyne cycloaddition reaction to form a stable triazole linkage with an azide labeled coupling partner
  • Can be used to create diverse conjugates with the biorthogonal coupling between an alkyne and azide (supplied separately)
  • The coupling or crosslinking procedure is typically done in two steps
    • First, a protein or amine containing molecule is labeled with a DBCO group and excess crosslinker is removed
    • Second, an azide containing moiety (prepared independently) is introduced into the same system as the DBCO moiety
    • Labeling occurs under biological conditions without the introduction of any additional reagents such as a copper catalyst
  • Ragent readily dissolves in water-miscible solvents for dilution into aqueous reaction mixtures
  • TFP esters are more hydrolytically stable than NHS esters
TRUSTED_SUSTAINABILITY

Specifications

Chemical Reactivity Amine-Azide
Cleavable No
Description TFP Ester-PEG4-DBCO
Molecular Weight (g/mol) 714.7
PEGylated Yes
Spacer Arm Length 17.9 Å
Content And Storage Upon receipt store desiccated at -20°C.
Cell Permeability Not determined
Shipping Condition Wet Ice
Product Line EZ-Link No-Weigh
Labeling Method Chemical Labeling
Crosslinker Type Heterobifunctional
Reactive Moiety TFP Ester, DBCO
Spacer Medium (10 to 30 Å)
Form Powder
Quantity 10 x 1 mg
Solubility DMF, DMSO
Format Standard, Single-use
Water Soluble No
Product Type Crosslinker
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