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  7. (+/-)-Equol, Thermo Scientific Chemicals

(+/-)-Equol, Thermo Scientific Chemicals

Catalog Number 15443989
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Quantity:
100 mg
500 mg
This item is not returnable. View return policy
94105-90-5
C15H14O3
242.27
MFCD00016662
ADFCQWZHKCXPAJ-UHFFFAOYNA-N
3-4-hydroxyphenyl chroman-7-ol, equol, +/--equol, r,s-equol, 7,4'-homoisoflavane, 4',7-dihydroxyisoflavane, rs-equol, 3-4-hydroxyphenyl-7-chromanol, 2h-1-benzopyran-7-ol, 3,4-dihydro-3-4-hydroxyphenyl, 4',7-isoflavandiol
382975
3-(4-hydroxyphenyl)-3,4-dihydro-2H-chromen-7-ol
OC1=CC=C(C=C1)C1COC2=C(C1)C=CC(O)=C2
This item is not returnable. View return policy
94105-90-5
C15H14O3
242.27
MFCD00016662
ADFCQWZHKCXPAJ-UHFFFAOYNA-N
3-4-hydroxyphenyl chroman-7-ol, equol, +/--equol, r,s-equol, 7,4'-homoisoflavane, 4',7-dihydroxyisoflavane, rs-equol, 3-4-hydroxyphenyl-7-chromanol, 2h-1-benzopyran-7-ol, 3,4-dihydro-3-4-hydroxyphenyl, 4',7-isoflavandiol
382975
3-(4-hydroxyphenyl)-3,4-dihydro-2H-chromen-7-ol
OC1=CC=C(C=C1)C1COC2=C(C1)C=CC(O)=C2

Description

Urinary metabolite of daidzein, produced by humans and horses

(±)-Equol exhibits EC50 values of 200 and 74 nM for human ERα and ERβ, respectively and induces breast cancer cell proliferation in vitro at concentrations as low as 100 nM. It is a weak estrogenic agonist, and competitive inhibitor of 17β-estradiol at the estradiol receptor. It inhibits 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced neoplastic cell transformation by targeting the MEK/ERK/p90RSK/activator protein-1 signalling pathway. It functions as a DHT blocker.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
(+/-)-Equol exhibits EC50 values of 200 and 74 nM for human ERα and ERβ, respectively and induces breast cancer cell proliferation in vitro at concentrations as low as 100 nM. It is a weak estrogenic agonist, and competitive inhibitor of 17β-estradiol at the estradiol receptor. It inhibits 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced neoplastic cell transformation by targeting the MEK/ERK/p90RSK/activator protein-1 signalling pathway. It functions as a DHT blocker.

Solubility
Soluble in DMSO and methanol or 100% ethanol. Insoluble in water.

Notes
Hygroscopic. Incompatible with oxidizing agents and heat.
TRUSTED_SUSTAINABILITY
Melting Point 172°C to 176°C
Color White
Quantity 100 mg
Beilstein 87752
Sensitivity Hygroscopic
Merck Index 14,3644
Solubility Information Soluble in DMSO and methanol or 100% ethanol. Insoluble in water.
Formula Weight 242.27
Physical Form Crystalline Powder
Chemical Name or Material (+/-)-Equol

RUO – Research Use Only

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