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  6. Thermo Scientific™ Dynabeads™ CaptureSelect™ AAVX Magnetic Beads

Thermo Scientific™ Dynabeads™ CaptureSelect™ AAVX Magnetic Beads

Product Code. 30276684 Shop All Thermo Scientific Products
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Capacity (Metric):
∼1 x 1012 viral particles/mg beads
Unit Size:
1mL
50mL
Each
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Product Code. Capacity (Metric) Unit Size
30276684 ∼1 x 1012 viral particles/mg beads Each
30276387 ∼1 x 1012 viral particles/mg beads 1mL
30276198 ∼1 x 1012 viral particles/mg beads 50mL
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Product Code. 30276684 Supplier Thermo Scientific™ Supplier No. 2853522005
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Description

Thermo Scientific™ Dynabeads™ CaptureSelect™ AAVX Magnetic Beads are high-capacity, high-throughput magnetic affinity particles for the purification of a broad range of naturally occurring and synthetic adeno-associated virus (AAV) serotypes used for gene therapy applications.

Dynabeads CaptureSelect AAVX Magnetic Beads are high-capacity, high-throughput magnetic affinity particles for the purification of a broad range of naturally occurring and synthetic adeno-associated virus (AAV) serotypes used for gene therapy applications. The anti-AAVX affinity ligand demonstrates good binding reactivity towards a large variety of AAV serotypes, including AAV1 to AAV8, AAVrh10, and synthetic serotypes. The magnetic beads enable purification using manual and robotic magnetic separators of AAV serotypes directly from crude feedstock in a single step with high purity and yield.

Features of DynaBeads CaptureSelect AAVX Magnetic Beads include:

  • One-magnetic-step AAV purification from crude material with high purity and yield
  • Compatible with manual and automated workflows
  • High specificity and capacity
  • Easy upscaling to higher volumes
  • Non-animal derived

Animal origin statement

CaptureSelect products contain affinity ligands based on recombinant single-domain antibody fragments (VHH) created by a proprietary technology. The VHH affinity ligand is a ∼12–15 kDa fragment comprising the three complementarity-determining regions (CDRs) that form the antigen-binding domain, efficiently produced in yeast Saccharomyces cerevisiae by a production process free of any animal components (Animal Origin-Free).

Main characteristics

  • Bead matrix: superparamagnetic
  • Bead size: 4.5 μm
  • Ligand: CaptureSelect AAVX affinity ligand
  • Binding capacity: ∼1 x1012 viral particles/mg beads
  • Elution conditions: 50 mM citric acid pH 2.5-3.0
  • Formulation buffer: tris-buffered saline, 0.05% Tween 20, 0.05 % sodium azide

Spezifikation

Binding Capacity ∼1 x 1012 viral particles/mg beads
Capacity (Metric) ∼1 x 1012 viral particles/mg beads
Concentration 30 mg beads/mL slurry, 1 mg contains approximately 1.3 x 107 beads
Formulation 4 to 6% (v/v) slurry in Tris buffered saline with 0.05% Tween 20 and 0.05% sodium azide
Matrix Non-porous monodisperse superparamagnetic beads
Content And Storage Store at 2°C to 8°C.
Particle Size 4.5 μm
Form Resin Slurry
Product Line CaptureSelect
Quantity 5 mL
For Use With (Application) Magnetic isolation of AAV capsids
Target Multiple AAV serotypes
Type Magnetic Affinity Bead
Ligand Type AAVX Affinity Ligand
Sufficient For Sample Preparation
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