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Tocris Bioscience™ DPTIP
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Product Code. 18789466
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18789466 10 mg 10mg
18767166 50 mg 50mg
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Product Code. 18789466 Supplier Tocris Bioscience™ Supplier No. 6903/10

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Description

Potent and selective N-SMase2 inhibitor; brain penetrant

DPTIP is a potent and selective sphingomyelin phosphodiesterase (N-SMase2) inhibitor (IC50 = 30 nM). Exhibits no inhibition of related enzymes alkaline phosphatase, phosphomonoesterase or acid sphingomyelinase. Inhibits extracellular vesicle (EV) release in primary astrocyte cultures and in vivo. Attenuates IL-1β-induced astrocyte-derived EV release in a mouse model of brain injury and suppresses infiltration of immune cells into the brain. Metabolically stable and brain penetrant.
TRUSTED_SUSTAINABILITY

Specifications

Quantity 10 mg
Molecular Formula C21H18N2O3S
Formula Weight 378.45
Product Type Inhibitor
Purity 98%
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