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R&D Systems™ CT-4

Product Code. 32058403
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5 mg
Unit Size:
5mg
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32058403 5 mg 5mg
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Product Code. 32058403 Supplier R&D Systems™ Supplier No. 8024/5
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Estimated Shipment: 02-11-2026
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Description

A Tocris product, part of R&D Systems. Potent and selective HDAC8 Degrader (PROTAC™)

CT-4 is a potent and selective histone deacetylase 8 (HDAC8) Degrader (PROTAC®) (DC50 = 1.8 nM after 24 h, Dmax 97%). Comprises a HDAC8-binding moiety joined by a linker to pomalidomide as the ligand for cereblon (CRBN) protein. Displays 20-fold selectivity over HDAC6 (DC50 = 38 nM after 24 h, Dmax 69%) and it does not degrade other HDACs. Displays significant effect on metastasis of MDA-MB-231 cells, and induces degradation and cell death in T-cell leukemia Jurkat cells. Outperformed HDAC8 inhibitors in oncology models. HDAC8 mediates signalling via scaffolding functions in HDAC8/p53/fusion protein complexes, also interacts with STAT3, cAMP and DEC1 via scaffolding functions.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license

TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material 3-((4-((8-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)octyl)carbamoyl)benzyl)oxy)-N-hydroxy-4-methoxybenzamide
CAS 3057302-21-0
Quantity 5 mg
Product Line Tocris
Target Histone Deacetylase Degraders
Molecular Formula C37H41N5O9
Purity 98%
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