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DiscoverX ChemiScreen™ Y2 Neuoropeptide Y Receptor Stable Cell Line

Product Code. 17305109
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Quantity:
2 Vials
Unit Size:
2 ampoules
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17305109 2 Vials 2 ampoules
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Product Code. 17305109 Supplier DiscoverX Supplier No. HTS066C

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Description

The ChemiScreen™ Y2 Neuoropeptide Y Receptor Stable Cell Line measures NPY2R (GPCR) activation via an increase in intracellular calcium. This cell line ships as two vials of cryopreserved cells.

The ChemiScreen™ Y2 Neuoropeptide Y Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. peptide YY) based activation of NPY2R GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses NPY2R alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of NPY2R , the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells.

Specifications

Assay Entry Calcium Flux
Cell Line Chem-1
For Use With (Application) Cell Lines
Primary Agonist Peptide YY, Human
Quantity 2 Vials
Target Entry NPY2R
Accession Number AY236540
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