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DiscoverX ChemiScreen™ TRH Thyrotropin-Releasing Hormone Receptor Stable Cell Line

Product Code. 17325249
Encompass
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Quantity:
2 Vials
Unit Size:
2 ampoules
This item is not returnable. View return policy

Product Code. 17325249

Brand: DiscoverX HTS126C

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This item is not returnable. View return policy

Description

The ChemiScreen™ TRH Thyrotropin-Releasing Hormone Receptor Stable Cell Line measures TRHR (GPCR) activation via an increase in intracellular calcium. This cell line ships as two vials of cryopreserved cells.

The ChemiScreen™ TRH Thyrotropin-Releasing Hormone Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. TRH) based activation of TRHR GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses TRHR alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of TRHR , the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells.

Specifications

Assay Entry Calcium Flux
Cell Line Chem-1
For Use With (Application) Cell Lines
Primary Agonist TRH
Quantity 2 Vials
Target Entry TRHR
Accession Number AY493373
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