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DiscoverX ChemiScreen™ SST2 Somatostatin Receptor Stable Cell Line

Product Code. 17305019
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Quantity:
2 Vials
Unit Size:
2 ampoules
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Product Code. Quantity unitSize
17305019 2 Vials 2 ampoules
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Product Code. 17305019 Supplier DiscoverX Supplier No. HTS028C

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Description

The ChemiScreen™ SST2 Somatostatin Receptor Stable Cell Line measures SSTR2 (GPCR) activation via an increase in intracellular calcium. This cell line ships as two vials of cryopreserved cells.

The ChemiScreen™ SST2 Somatostatin Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. somatostatin) based activation of SSTR2 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses SSTR2 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of SSTR2 , the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells.

Specifications

Assay Entry Calcium Flux
Cell Line Chem-1
For Use With (Application) Cell Lines
Primary Agonist Somatostatin 28
Quantity 2 Vials
Target Entry SSTR2
Accession Number AY236542
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