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DiscoverX ChemiScreen™ NOP/ORL1 Opioid Receptor Stable Cell Line

Product Code. 17395039
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Quantity:
2 Vials
Unit Size:
2 ampoules
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17395039 2 Vials 2 ampoules
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Product Code. 17395039 Supplier DiscoverX Supplier No. HTS040C

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Description

The ChemiScreen™ NOP/ORL1 Opioid Receptor Stable Cell Line measures OPRL1 (GPCR) activation via an increase in intracellular calcium. This cell line ships as two vials of cryopreserved cells.

The ChemiScreen™ NOP/ORL1 Opioid Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. orphanin FQ) based activation of OPRL1 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses OPRL1 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of OPRL1, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells.

Spécification

Assay Entry Calcium Flux
Cell Line Chem-1
For Use With (Application) Cell Lines
Primary Agonist Orphanin FQ
Quantity 2 Vials
Target Entry OPRL1
Accession Number AY268428
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