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DiscoverX ChemiScreen™ MRGPRX2 Receptor Stable Cell Line

Product Code. 17395079
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Quantity:
2 Vials
Unit Size:
2 ampoules
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17395079 2 Vials 2 ampoules
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Product Code. 17395079 Supplier DiscoverX Supplier No. HTS058C

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Description

The ChemiScreen™ MRGPRX2 Receptor Stable Cell Line measures MRGPRX2 (GPCR) activation via an increase in intracellular calcium. This cell line ships as two vials of cryopreserved cells.

The ChemiScreen™ MRGPRX2 Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. cortistatin-14, PAMP) based activation of MRGPRX2 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses MRGPRX2 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of MRGPRX2, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells.

Specifications

Assay Entry Calcium Flux
Cell Line Chem-1
Format 2 vials
For Use With (Application) Cell Lines
Primary Agonist Proadrenomedullin fragment, 1-20 (PAMP)
Quantity 2 Vials
Target Entry MRGPRX2
Accession Number NM_054030.2
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