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DiscoverX ChemiScreen™ CysLT2 Leukotriene Receptor Stable Cell Line

Product Code. 17305159
Encompass
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Quantity:
2 Vials
Unit Size:
2 ampoules
This item is not returnable. View return policy

Product Code. 17305159

Brand: DiscoverX HTS088C

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This item is not returnable. View return policy

Description

The ChemiScreen™ CysLT2 Leukotriene Receptor Stable Cell Line measures CYSLTR2 (GPCR) activation via an increase in intracellular calcium. This cell line ships as two vials of cryopreserved cells.

The ChemiScreen™ CysLT2 Leukotriene Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. leukotriene) based activation of CYSLTR2 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses CYSLTR2 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of CYSLTR2 , the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells.

Specifications

Assay Entry Calcium Flux
Cell Line Chem-1
For Use With (Application) Cell Lines
Primary Agonist Leukotriene C4
Quantity 2 Vials
Target Entry CYSLTR2
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