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DiscoverX ChemiScreen™ CCR6 Chemokine Receptor Stable Cell Line

Product Code. 17354969
Encompass
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Quantity:
2 Vials
Unit Size:
2 ampoules
This item is not returnable. View return policy

Product Code. 17354969

Brand: DiscoverX HTS011C

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This item is not returnable. View return policy

Description

The ChemiScreen™ CCR6 Chemokine Receptor Stable Cell Line measures CCR6 (GPCR) activation via an increase in intracellular calcium. This cell line ships as two vials of cryopreserved cells.

The ChemiScreen™ CCR6 Chemokine Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. CCL20) based activation of CCR6 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses CCR6 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of CCR6 , the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells.

Specifications

Assay Entry Calcium Flux
Cell Line Chem-1
For Use With (Application) Cell Lines
Primary Agonist Recombinant Human MIP-3α (CCL20)
Quantity 2 Vials
Target Entry CCR6
Accession Number AY242126
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