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DiscoverX ChemiScreen™ β1 Adrenoceptor Receptor Stable Cell Line

Product Code. 17315209
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Quantity:
2 Vials
Unit Size:
2 ampoules
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17315209 2 Vials 2 ampoules
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Product Code. 17315209 Supplier DiscoverX Supplier No. HTS104C

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Description

The ChemiScreen™ β1 Adrenoceptor Receptor Stable Cell Line measures ADRB1 (GPCR) activation via an increase in intracellular calcium. This cell line ships as two vials of cryopreserved cells.

The ChemiScreen™ β1 Adrenoceptor Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. epinephrine and norepinephrine) based activation of ADRB1 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses ADRB1 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of ADRB1 , the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells.

Specifications

Assay Entry Calcium Flux
Cell Line Chem-1
For Use With (Application) Cell Lines
Primary Agonist Epinephrine
Quantity 2 Vials
Target Entry ADRB1
Accession Number NM_000684
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