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DiscoverX ChemiBrite™ GPBA Bile Acid Receptor Stable Cell Line

Product Code. 17375389
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Quantity:
2 Vials
Unit Size:
2 ampoules
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17375389 2 Vials 2 ampoules
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Product Code. 17375389 Supplier DiscoverX Supplier No. HTS238L

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Description

The ChemiBrite™ GPBA Bile Acid Receptor Stable Cell Line measures GPBAR1 (GPCR) activation via an increase in intracellular calcium. This cell line ships as two vials of cryopreserved cells.

The ChemiBrite GPBA Bile Acid Receptor cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. lithocholic acid, other bile acids) based activation of GPBAR1 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses GPBAR1 alongside exogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. ChemiBrite cells also express a clytin variant, allowing for luminescent as well as fluorescent signal detection. Upon activation of GPBAR1 , the resulting calcium activity can be assayed in either detection mode. This stable modified cell line is provided as two vials of cryopreserved cells.

Specifications

Assay Entry Calcium Flux
Cell Line 293H
For Use With (Application) Cell Lines
Primary Agonist Lithocholic Acid
Quantity 2 Vials
Target Entry GPBAR1
Accession Number NM_001077194.1
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