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CD8 Mouse anti-Human, PE, Clone: RPA-T8, BD
Mouse Monoclonal Antibody
Brand: BD Biosciences 561950
Additional Details : Weight : 0.02000kg
Description
The RPA-T8 monoclonal antibody specifically binds to CD8 alpha (CD8α) . CD8α is a type I transmembrane glycoprotein and a member of the immunoglobulin superfamily. CD8α is expressed by the majority of thymocytes, by subpopulations of αβ T cells and γδ T cells and by some NK cells. Cell surface CD8α is expressed either as a disulfide-linked homodimer (CD8αα) αβ T cells coexpress both CD8αα homodimers and CD8αβ heterodimers whereas some γδ T cells and NK cells express CD8αα homodimers. CD8 plays important roles in T cell activation and selection. The extracellular IgSF domain of CD8 α binds to a non-polymorphic determinant on HLA class I molecules (α3 domain) and enables CD8 to function as a co-receptor with MHC class I-restricted TCR during T cell recognition of antigen. The cytoplasmic domain of CD8α associates with Lck, a Src family protein tyrosine kinase that is involved in intracellular signaling. The RPA-T8 and HIT8a monoclonal antibodies are not cross-blocking. This clone has been reported to react with a subset of peripheral blood lymphocytes, but not monocytes nor granuloyctes, of baboon and both rhesus and cynomolgus macaque monkey. In general, a higher frequency of CD8+ and CD4+CD8+ lymphocytes are observed in non-human primates compared to normal human donors.
Specifications
| CD8 | |
| Monoclonal | |
| PE | |
| Aqueous buffered solution containing BSA, protein stabilizer, and ≤0.09% sodium azide. | |
| Human CD8a | |
| 500 Tests | |
| Primary | |
| Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
| Flow Cytometry | |
| RPA-T8 | |
| CD8α; CD8A; CD8 alpha; Leu2; MAL; T8; p32 | |
| Mouse | |
| Affinity Purified | |
| RUO | |
| Baboon, Cynomolgus, Human, Rhesus Monkey | |
| IgG1 κ |
For Research Use Only.