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CD279 Mouse anti-Human, PE, Clone: MIH4, BD
Mouse Monoclonal Antibody
221.00€ - 481.00€
Specifications
| Antigen | CD279 |
|---|---|
| Clone | MIH4 |
| Applications | Flow Cytometry |
| Classification | Monoclonal |
| Conjugate | PE |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|
15820589
|
BD Biosciences
560908 |
25 Tests |
221.00€
Each |
Estimated Shipment: 04-06-2024
Log in to see stock. |
|||||
|
15839128
|
BD Biosciences
557946 |
100 Tests |
481.00€
Each |
Estimated Shipment: 04-06-2024
Log in to see stock. |
|||||
Description
The MIH4 monoclonal antibody specifically binds to the program death 1 (PD-1) receptor CD279, a member of the Ig superfamily. CD279 is an immunoregulatory receptor expressed on activated T cells, B cells and myeloid cells. Mice deficient in CD279 show a breakdown of peripheral tolerance and manifest multiple autoimmune symptoms. It contains an immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region. PD-L1 and PD-L2 are ligands of CD279 and are members of the B7 gene family. Interaction of CD279:PD-Ligands results in inhibition of T cell proliferation and cytokine secretion. Reports suggest that the B7/CTLA-4 pathway functions primarily to attenuate, limit, and/or terminate naοve T-cell activation in secondary lymphoid organs. The PD-ligand:CD279 pathway, on the other hand, may primarily attenuate, limit, and/or terminate T-, B-, and myeloid cell activation/effector function at sites of inflammation in the periphery.
Specifications
| CD279 | |
| Flow Cytometry | |
| PE | |
| RUO | |
| Aqueous buffered solution containing BSA and ≤0.09% sodium azide. | |
| IgG1 κ | |
| Affinity Purified | |
| PD-1; hPD-1; PD1; PDCD1; Programmed cell death 1; SLEB2 |
| MIH4 | |
| Monoclonal | |
| Mouse | |
| Human | |
| Human PD-1 Transfected Cell Line | |
| Primary | |
| Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
For Research Use Only.