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DiscoverX cAMP Hunter™ CHO-K1 PTHR1 Gs Cell Line

Product Code. 17394619
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Quantity:
2 Vials
Unit Size:
2 ampoules
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17394619 2 Vials 2 ampoules
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Product Code. 17394619 Supplier DiscoverX Supplier No. 950118C2

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Description

The cAMP Hunter™ CHO-K1 PTHR1 Gs Cell Line measures PTHR1 (GPCR) activity via increased levels of intracellular cAMP. This cell line ships as two vials of cryopreserved cells.

The cAMP Hunter PTHR1 Gs cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. parathyroid hormone) based activation of PTHR1 GPCR activity via detection of increasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wildtype PTHR1, a naturally Gs coupled GPCR. Upon activation of PTHR1, the increase in levels of intracellular cAMP leads to an increased signal from EFC when the cAMP detection kit is applied. This stable modified cell line is provided as two vials of cryopreserved cells.

Specifications

Assay Entry Intracellular cAMP level
Cell Line CHO-K1
For Use With (Application) Cell Lines
Primary Agonist PTH(1-34)
Quantity 2 Vials
Target Entry PTHR1
Accession Number AY449732
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