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DiscoverX cAMP Hunter™ CHO-K1 PPYR1 (NPY4R) Gi Cell Line

Product Code. 17314559
Encompass
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Quantity:
2 Vials
Unit Size:
2 ampoules
This item is not returnable. View return policy

Product Code. 17314559

Brand: DiscoverX 950087C2

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This item is not returnable. View return policy

Description

The cAMP Hunter™ CHO-K1 PPYR1 (NPY4R) Gi Cell Line measures PPYR1 (GPCR) activity via decreased levels of intracellular cAMP. This cell line ships as two vials of cryopreserved cells.

The cAMP Hunter PPYR1 (NPY4R) Gi cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. pancreatic polypeptide, peptide YY) based activation of PPYR1 GPCR activity via detection of decreasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wildtype PPYR1 , a naturally Gi/Go coupled GPCR. Upon activation of PPYR1 , the decrease in levels of intracellular cAMP leads to a decreased signal from EFC when the cAMP detection kit is applied. This stable modified cell line is provided as two vials of cryopreserved cells.

Specifications

Assay Entry Intracellular cAMP level
Cell Line CHO-K1
For Use With (Application) Cell Lines
Primary Agonist Pancreatic polypeptide
Quantity 2 Vials
Target Entry PPYR1 (NPY4R)
Accession Number AY268432
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