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DiscoverX cAMP Hunter™ CHO-K1 GPR35 Gi Cell Line

Product Code. 17314689
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Quantity:
2 Vials
Unit Size:
2 ampoules
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Product Code. Quantity unitSize
17314689 2 Vials 2 ampoules
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Product Code. 17314689 Supplier DiscoverX Supplier No. 950152C2

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Description

The cAMP Hunter™ CHO-K1 GPR35 Gi Cell Line measures GPR35 (GPCR) activity via decreased levels of intracellular cAMP. This cell line ships as two vials of cryopreserved cells.

The cAMP Hunter GPR35 Gi cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. zaprinast) based activation of GPR35 GPCR activity via detection of decreasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wildtype GPR35 , a naturally Gi/Go coupled GPCR. Upon activation of GPR35 , the decrease in levels of intracellular cAMP leads to a decreased signal from EFC when the cAMP detection kit is applied. This stable modified cell line is provided as two vials of cryopreserved cells.

Specifications

Assay Entry Intracellular cAMP level
Cell Line CHO-K1
For Use With (Application) Cell Lines
Primary Agonist Zaprinast
Quantity 2 Vials
Target Entry GPR35
Accession Number NM_005301
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