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DiscoverX cAMP Hunter™ CHO-K1 GPR109A Gi Cell Line

Product Code. 17304639
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Quantity:
2 Vials
Unit Size:
2 ampoules
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17304639 2 Vials 2 ampoules
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Product Code. 17304639 Supplier DiscoverX Supplier No. 950122C2

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Description

The cAMP Hunter™ CHO-K1 GPR109A Gi Cell Line measures GPR109A (GPCR) activity via decreased levels of intracellular cAMP. This cell line ships as two vials of cryopreserved cells.

The cAMP Hunter GPR109A Gi cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. nicotinic acid) based activation of GPR109A GPCR activity via detection of decreasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wildtype GPR109A , a naturally Gi/Go coupled GPCR. Upon activation of GPR109A , the decrease in levels of intracellular cAMP leads to a decreased signal from EFC when the cAMP detection kit is applied. This stable modified cell line is provided as two vials of cryopreserved cells.

Specifications

Assay Entry Intracellular cAMP level
Cell Line CHO-K1
For Use With (Application) Cell Lines
Primary Agonist Nicotinic acid
Quantity 2 Vials
Target Entry GPR109A
Accession Number NM_177551
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