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DiscoverX cAMP Hunter™ CHO-K1 CXCR4 Gi Cell Line

Product Code. 17354539
Encompass
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Quantity:
2 Vials
Unit Size:
2 ampoules
This item is not returnable. View return policy

Product Code. 17354539

Brand: DiscoverX 950081C2

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This item is not returnable. View return policy

Description

The cAMP Hunter™ CHO-K1 CXCR4 Gi Cell Line measures CXCR4 (GPCR) activity via decreased levels of intracellular cAMP. This cell line ships as two vials of cryopreserved cells.

The cAMP Hunter CXCR4 Gi cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. CXCL12/SDF-1α) based activation of CXCR4 GPCR activity via detection of decreasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wildtype CXCR4 , a naturally Gi/Go coupled GPCR. Upon activation of CXCR4 , the decrease in levels of intracellular cAMP leads to a decreased signal from EFC when the cAMP detection kit is applied. This stable modified cell line is provided as two vials of cryopreserved cells.

Specifications

Assay Entry Intracellular cAMP level
Cell Line CHO-K1
For Use With (Application) Cell Lines
Primary Agonist Recombinant Human SDF-1α (CXCL12)
Quantity 2 Vials
Target Entry CXCR4
Accession Number AY242129
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