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DiscoverX cAMP Hunter™ CHO-K1 ADORA3 Gi Cell Line

Product Code. 17324589
Encompass
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Quantity:
2 Vials
Unit Size:
2 ampoules
This item is not returnable. View return policy

Product Code. 17324589

Brand: DiscoverX 950101C2

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This item is not returnable. View return policy

Description

The cAMP Hunter™ CHO-K1 ADORA3 Gi Cell Line measures ADORA3 (GPCR) activity via decreased levels of intracellular cAMP. This cell line ships as two vials of cryopreserved cells.

The cAMP Hunter ADORA3 Gi cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. adenosine, NECA) based activation of ADORA3 GPCR activity via detection of decreasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wildtype ADORA3 , a naturally Gi/Go coupled GPCR. Upon activation of ADORA3 , the decrease in levels of intracellular cAMP leads to a decreased signal from EFC when the cAMP detection kit is applied. This stable modified cell line is provided as two vials of cryopreserved cells.

Specifications

Assay Entry Intracellular cAMP level
Cell Line CHO-K1
For Use With (Application) Cell Lines
Primary Agonist 2-Cl-IB-MECA
Quantity 2 Vials
Target Entry ADORA3
Accession Number NM_000677.3
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