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Calreticulin Mouse, Unlabeled, Clone: 16, BD
Mouse Monoclonal Antibody
343.00€ - 650.00€
Specifications
| Antigen | Calreticulin |
|---|---|
| Clone | 16 |
| Concentration | 250μg/mL |
| Applications | Western Blot |
| Classification | Monoclonal |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|
15836109
|
BD Biosciences
612136 |
50 μg |
343.00€
1 set |
Estimated Shipment: 11-06-2024
Log in to see stock. |
|||||
|
15846109
|
BD Biosciences
612137 |
150 μg |
650.00€
1 set |
Estimated Shipment: 11-06-2024
Log in to see stock. |
|||||
Description
Proteins undergo numerous modifications, including folding, translocation, and degradation. During such modifications, polypeptides are rarely in a native, stable state. Molecular chaperones are a diverse group of proteins that modulate polypeptide stability through ATP-dependent folding. Many chaperone proteins are found in the endoplasmic reticulum (ER). Calreticulin is a luminal ER protein that is 39% homologous to the ER chaperone protein, calnexin. Calreticulin contains a C-terminal KDEL ER retention signal, and can bind Ca2+;, Zn2+, ATP, and the proteins, ERp57 and protein disulfide isomerase. The molecular chaperone activities of calreticulin may include folding of both Asn-linked glycoproteins and non-glycosylated proteins. In addition, calreticulin is a component of MHC I/transporter associated with Ag presentation (TAP) complex where it may function in peptide assembly onto nascent class I molecules. Calreticulin may also function in integrin signaling, since it binds a3-integrin subunits and regulates integrin-mediated metalloprotease secretion. Thus, calreticulin may be involved in Ca2+; storage, cell adhesion, and protein folding.
Immunofluorescence, Western Blotting
Specifications
| Calreticulin | |
| 250μg/mL | |
| Monoclonal | |
| Mouse | |
| Cell Biology | |
| Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
| IgG1 | |
| Affinity Purified |
| 16 | |
| Western Blot | |
| Unconjugated | |
| RUO | |
| Human, Mouse, Rat | |
| Mouse Calreticulin aa. 270-390 | |
| Primary | |
| Store undiluted at -20°C. |
For Research Use Only.