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Berberine chloride

Product Code. 15424719
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Product Code. 15424719 Supplier Thermo Scientific Alfa Aesar Supplier No. J62311.06
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Description

CAS: 633-65-8 | C20H18ClNO4 | 371.817 g/mol

Berberine is an isoqinoline alkaloid shown to have a chemopreventive property against colon tumor formation by inhibiting the enzyme Cox-2 (cyclooxygenase-2) which is abundantly expressed in colon cancer cells. Also inhibits c-Jun (Activator Protein 1), a transcription factor that plays a critical role in inflammation and carcinogenesis. Berberine upregulates the expression of Pgp in hepatoma cells. Treatment with berberine potentially results in the reduced accumulation of chemotherapeutic drugs.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Solubility
Soluble in dimethyl sulfoxide (74 mg/ml at 25°C), ethanol (<1mg/mL at 25°C), water (<1mg/mL at 25°C), and methanol.

Notes
Store at -20°C. Incompatible with oxidizing agents. Protect from heat.
TRUSTED_SUSTAINABILITY

Specifications

CAS 633-65-8
Color Yellow to Orange
Molecular Formula C20H18ClNO4
MDL Number MFCD00011939
Quantity 5 g
Beilstein 3836585
Synonym berberine chloride, berberine hydrochloride, natural yellow 18, benzodioxide, berberinium chloride, berberine hcl, unii-uot4o1byv8, berberine chloride jan, uot4o1byv8
Solubility Information Soluble in dimethyl sulfoxide (74mg/ml at 25°C),ethanol (<1mg/ml at 25°C),water (<1mg/ml at 25°C),and methanol.
InChI Key VKJGBAJNNALVAV-UHFFFAOYSA-M
SMILES COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC5=C(C=C4CC3)OCO5)OC.[Cl-]
Molecular Weight (g/mol) 371.817
PubChem CID 12456
ChEBI CHEBI:31271
Formula Weight 371.82
Physical Form Powder
Chemical Name or Material Berberine chloride
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