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  5. Tocris Bioscience™ BAY 678

Tocris Bioscience™ BAY 678
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Product Code. p-7116081
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5 mg
25 mg
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25mg
5mg
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Product Code. Quantity unitSize
18741429 25 mg 25mg
18739278 5 mg 5mg
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Product Code. 18741429 Supplier Tocris Bioscience™ Supplier No. 5706/25

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Description

Potent and selective cell-permeable human neutrophil elastase (HNE) inhibitor

BAY 678 is a potent and selective cell-permeable human neutrophil elastase (HNE) inhibitor (IC50 = 20 nM). Exhibits around 2000-fold selectivity for NHE against a panel of 21 other serine proteases. Effective in an acute lung injury model in vivo. Orally bioavailable. Inactive S-enantiomer (Cat.No.6389) also available.
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Specifications

Chemical Name or Material 5-[(4R)-5-Acetyl-1,2,3,4-tetrahydro-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-4-pyrimidinyl]-2-pyridinecarbonitrile
CAS 675103-36-3
Assay Percent Range >98%
Quantity 25 mg
Molecular Formula C20H15F3N4O2
Formula Weight Observed MW: 400.35
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