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Tocris Bioscience™ AZD 1480
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Product Code. 18704729
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Quantity:
10 mg
Unit Size:
10mg
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Product Code. 18704729

Brand: Tocris Bioscience™ 5617/10

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This item is not returnable. View return policy

Description

Potent and selective JAK2 inhibitor; antiangiogenic

AZD 1480 is a potent and selective JAK2 inhibitor (IC50 < 3 nM). Exhibits >50-fold selectivity for JAK2 over JAK3. Exhibits antitumor effects and inhibits formation of lung metastases in a mouse renal cancer model. Also inhibits STAT3 signaling, tumor angiogenesis and myeloid cell migration in vivo.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material 5-Chloro-N2-[(1S)-1-(5-fluoro-2-pyrimidinyl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)-2,4-pyrimidine-2,4-diamine
CAS 935666-88-9
Quantity 10 mg
Target JAK Kinase Inhibitors
Molecular Formula C14H14ClFN8
Formula Weight 348.77
Purity >98%
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