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Tocris Bioscience™ AT 101
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Product Code. 18095812
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Quantity:
10 mg
50 mg
Unit Size:
10mg
50mg
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Product Code. 18095812

Brand: Tocris Bioscience™ 3367/50

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Description

Downregulates Bcl-2 and Mcl-1; pro-apoptotic

R-(-)-enantiomer of gossypol (Cat. No. 1964). Mimics the BH3 domains of Bcl-2, Bcl-XL and Mcl-1. Disrupts heterodimerization of Bcl-2 with proapoptotic family members. Induces apoptosis in vitro through activation of caspase-9; cytotoxic to multiple myeloma and drug-resistant cell lines. Delays onset of androgen-independent growth of VCaP prostate cancer xenografts in vivo.
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Chemical Identifiers

CAS 90141-22-3
Molecular Formula C30H30O8

Specifications

Quantity 50 mg
Formula Weight 518.56
Purity >98%
Molecular Weight (g/mol) 518.562
Chemical Name or Material AT 101
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