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  5. Tocris Bioscience™ AS 2444697

Tocris Bioscience™ AS 2444697
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Product Code. p-7110823
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Quantity:
10 mg
50 mg
Unit Size:
10mg
50mg
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Product Code. 18751678

Brand: Tocris Bioscience™ 5430/10

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Description

Potent and selective IRAK4 inhibitor

AS 2444697 is a potent and selective interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor (IC50 = 21 nM). Displays 30-fold selectivity for IRAK4 over IRAK1. Inhibits LPS-induced TNF-α and IL-6 production in PBMCs in vitro. Renoprotective and anti-inflammatory in a rodent model of chronic kidney disease.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material N-[3-Aminocarbonyl)-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl]-2-(2-methyl-4-pyridinyl)-4-oxazolecarboxamide hydrochloride
CAS 1287665-60-4
Quantity 10 mg
Target Other Kinase Inhibitors
Molecular Formula C19H20N6O4.HCl
Formula Weight 432.86
Purity >98%
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