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Tocris Bioscience™ ARN 14494
Potent serine palmitoyltransferase inhibitor
Brand: Tocris Bioscience™ 7134/50
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Description
ARN 14494 is a potent serine palmitoyltransferase inhibitor (IC50 = 27.3 nM). ARN 14494 inhibits synthesis of long chain ceramides and dihydroceramides in an in vitro model of Alzheimer's diease. The compound prevents the synthesis of proinflammatory cytokines and the oxidative stress-related enzymes iNOS and COX-2 in mouse primary cortical astrocytes. ARN 14494 is neuroprotective against β-amyloid 1-42 induced neurotoxicity in primary cortical neurons co-cultured with astrocytes.
Specifications
| rel-1-[1-[2-[(3 aR,6 AS)-Hexahydrocyclopenta[c]pyrrol-2(1 H)-yl]-2-oxoethyl]-4-piperidinyl]-2,3-dihydro-N-methyl-2-oxo-1 H-indole-5-carboxamide | |
| 50 mg | |
| C24H32N4O3 |
| 1037834-43-7 | |
| Other Transferase Inhibitors | |
| 0.98 |
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