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Nesprin 1 Monoclonal Antibody (MANNES1A(7A12)), Invitrogen™
Mouse Monoclonal Antibody
Brand: Invitrogen MA518077
Additional Details : Weight : 0.01000kg
Description
This antibody recognizes the C-terminal region of nesprin-1. This target has a predicted molecular weight of 1011 kDa.
There are two genes encoding members of a new family of type II integral membrane proteins. Both are ubiquitously expressed, and tissue-specific alternative mRNA initiation and splicing generate at least two major isoforms of each protein, with the smaller isoforms being truncated at the N-terminus. These proteins are called nesprin-l and -2 for nuclear _envelope _spectrin repeat, as they are characterized by the presence of multiple, clustered spectrin repeats, bipartite nuclear localization sequences and a conserved C-terminal, single transmembrane domain. Transient transfection of EGFP-fusion expression constructs demonstrated their localization to the nuclear membrane with a novel C-terminal, TM-domain-containing sequence essential for perinuclear localization. Nesprin-l is developmentally regulated in both smooth and skeletal muscle and is relocalized from the nuclear envelope to the nucleus and cytoplasm during C2Cl2 myoblast differentiation. Nesprins may function as 'dystrophins of the nucleus' to maintain nuclear organization and structura integrity.Specifications
Nesprin 1 | |
Monoclonal | |
1 mg/mL | |
PBS with 0.1% sodium azide | |
Q6ZWR6, Q8NF91 | |
SYNE1 | |
Recombinant full length Nesprin 1(Human) | |
100 μL | |
Primary | |
Human, Mouse, Rabbit, Rat | |
Antibody | |
IgG1 |
Immunocytochemistry, Western Blot | |
MANNES1A(7A12) | |
Unconjugated | |
SYNE1 | |
8B; A330049M09Rik; ARCA1; BE692247; C130039F11Rik; C6orf98; CPG2; CPG2 full length; dJ45H2.2; DKFZp781J13156; EDMD4; enaptin; enaptin165; FLJ30878; FLJ41140; KASH domain-containing protein 1; KASH1; KIAA0796; KIAA1262; KIAA1756; mKIAA1756; MYNE1; Myne-1; Myocyte nuclear envelope protein 1; Nesp1; nesprin 1; nesprin-1; Nuclear envelope spectrin repeat protein 1; RP1-130E4.2; SCAR8; spectrin repeat containing nuclear envelope protein 1; spectrin repeat containing, nuclear envelope 1; synaptic nuclear envelope 1; synaptic nuclear envelope protein 1; synaptic nuclei expressed gene 1; SYNE 1; SYNE1; Syne-1; syne-1 fragment | |
Mouse | |
Protein G | |
RUO | |
100347993, 23345, 499010, 64009 | |
Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C | |
Liquid |
Safety and Handling
- Nesprin 1 Monoclonal Antibody (MANNES1A(7A12))
Signal Word
- Warning
Hazard Category
- Acute toxicity Category 4
Hazard Statement
- H302-Harmful if swallowed.
Precautionary Statement
- P260-Do not breathe dust/fume/gas/mist/vapours/spray.
- P264-Wash hands thoroughly after handling.
- P301+P310-IF SWALLOWED: Immediately call a POISON CENTER/doctor /
- P501b-Dispose of contents/container in accordance with local/regional/national/international regulations.
Supplemental information
- MIXTURE LIST-Contains : sodium azide