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Gαq Mouse, Unlabeled, Clone: 10, BD
Mouse Monoclonal Antibody
Brand: BD Biosciences 612704
Additional Details : Weight : 0.01000kg
Description
The GTP binding regulatory proteins (G proteins) consist of three subunits: α, β, and γ. These heterotrimeric proteins function at membranes to relay signals from cell surface receptors to intracellular effectors. The α subunit is unique for each G protein and contains the site of GTP binding and hydrolysis, as well sites for receptor and effector interactions. The βγ subunit complex interacts directly with receptors and the α subunit. The Gα family includes four families: the Gαs family including Gαs , Gαo1f, and Gαt, the Gαi family including Gαi, Gαo, and Gαz, the Gαq/Gα11 family and the Gα12/13 family. The Gαq protein is 88% homologus with Gα11 and both are widely expressed. These G proteins activate phospholipase C proteins, which induce calcium signaling events. G protein coupled receptors (GPCRs) involved in regulating Wnt signaling activate Gαq, phospholipase Cβ, and induce calcium-dependent activation of calpain. These events promote β-catenin nuclear export and proteolysis. Gαq has also been implicated in metabotropic glutamate receptor signaling. Thus, Gαq isoforms activate phospholipase C proteins in various G-protein coupled receptor pathways.
Immunofluorescence, Western Blotting
Specifications
| Gαq | |
| Monoclonal | |
| 250μg/mL | |
| Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
| Human Gαq aa. 22-31 | |
| 50 μg | |
| Cell Biology | |
| Canine, Chicken, Human, Mouse, Rat | |
| IgG1 |
| Western Blot | |
| 10 | |
| Unconjugated | |
| Mouse | |
| Affinity Purified | |
| RUO | |
| Primary | |
| Store undiluted at -20°C. |
For Research Use Only.