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Dynactin p50 Mouse, Unlabeled, Clone: 25, BD
Mouse Monoclonal Antibody
321.00€ - 445.83€
Specifications
Antigen | Dynactin p50 |
---|---|
Clone | 25 |
Concentration | 250μg/mL |
Applications | Western Blot |
Classification | Monoclonal |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
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Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
15815759
|
BD Biosciences
611002 |
50 μg |
321.00€
1 set |
Estimated Shipment:
Log in to see stock. |
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15825759
|
BD Biosciences
611003 |
150 μg |
This item has been discontinued and is no longer available. View the product for possible alternatives or contact our Technical Support team on +351 21 425 33 50 for assistance |
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Description
Dyneins are ubiquitous, multimeric proteins that are responsible for minus end-directed microtubule-based organelle transport. They are divided into two classes, cytosolic and axonemal. The activity of cytosolic dynein is regulated by the multiprotein dynactin complex with which it co-purifies. Dynactin is composed of at least nine polypeptides with p50 being the second most abundant subunit. The complex consists of an F-actin-like core filament of actin-related protein Arp1, a heterodimer that acts as a cap at one end, and a 62kDa subunit at the other end. p150[glued] is the largest subunit of the complex. The precise function of dynactin remains to be determined, but it may be recruited to prometaphase kinetochores to assist in alignment and spindle organization during mitosis. Additionally, dynactin localizes at the tail of cytosolic dynein and activates dynein-mediated vesicle movement. Therefore, dynactin may function to anchor or target dynein to the kinetochore during mitosis.Specifications
Dynactin p50 | |
250μg/mL | |
Monoclonal | |
Mouse | |
Cell Biology | |
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
IgG1 | |
Affinity Purified |
25 | |
Western Blot | |
Unconjugated | |
RUO | |
Drosophila, Human, Mouse, Rat | |
Human Dynactin p50 aa. 55-196 | |
Primary | |
Store undiluted at -20°C. |
For Research Use Only.