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Tocris Bioscience™ Adenosine 5'-(a,b-methylene)diphosphate disodium salt
Ecto-5'-nucleotidase (CD73) inhibitor
Brand: Tocris Bioscience™ 8173/10
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Description
Adenosine 5'-(α,β-methylene)diphosphate sodium salt is an ecto-5'-nucleotidase/CD73 inhibitor. Blocks ecto-5'-nucleotidase-mediated adenosine production by preventing the conversion of AMP to adenosine. Reverses doxorubicin -resistance in ecto-5'-nucleotidase-positive MDR cells (MCF7/A6 and L1210/A). Also increases rhodamine uptake and inhibits rhodamine efflux from ecto-5'-nucleotidase-positive MDR cells. Vasoconstrictor, induces inflammation in a rodent model of pleurisy, and reduces memory loss induced by Aβ1-42 in a mouse model of Alzheimer's disease.
Specifications
| α,β-Methyleneadenosine 5'-diphosphate disodium salt | |
| 10 mg | |
| C11H15N5Na2O9P2 |
| 104835-70-3 | |
| 5'-Nucleotidase/CD73 | |
| 0.98 |
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