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  5. Tocris Bioscience™ Adavosertib

Tocris Bioscience™ Adavosertib
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Product Code. 18777586
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50 mg
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Product Code. Quantity unitSize
18777586 10 mg 10mg
18758086 50 mg 50mg
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Product Code. 18777586

Brand: Tocris Bioscience™ 7589/10

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Description

Potent and selective Wee1 inhibitor

Adavosertib is a potent and selective Wee1 inhibitor (IC50 = 5.2 nM). In a panel of 223 serine/threonine or tyrosine kinases, Adavosertib is highly selective for Wee 1 over all except 8 kinases. In particular Adavosertib shows >100-fold selectivity over human Myt1. Adavosertib blocks CDC2Y15 phosphorylation and Gemcitabine (Cat. No. 3259)-induced DNA damage checkpoint, leading to premature mitotic entry and apoptosis in p53-deficient tumor cell lines. Adavosertib also potentiates the cytotoxic effects of Pemetrexed (Cat. No. 6185), Doxorubicin (Cat. No. 2252), Camptothecin (Cat. No. 1100) and Mitomycin C (Cat. No. 3258) in vitro. Adavosertib synergizes with gemcitabine to achieve tumor regressions, selectively in p53-deficient pancreatic cancer xenografts.
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Specifications

Chemical Name or Material 1,2-Dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-(2-propen-1-yl)-3 H-pyrazolo[3,4-d]pyrimidin-3-one
CAS 955365-80-7
Quantity 10 mg
Target Checkpoint Control Kinase Inhibitors
Molecular Formula C27H32N8O2
Purity 98%
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