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ADAM10 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Invitrogen PA587899
Additional Details : Weight : 0.01000kg
Description
Positive Samples: HT-1080, Raji, Jurkat, Mouse kidney, Mouse brain; Cellular Location: Cell membrane, Endomembrane system, Single-pass type I membrane protein Immunogen sequence: EKNTCQLYIQ TDHLFFKYYG TREAVIAQIS SHVKAIDTIY QTTDFSGIRN ISFMVKRIRI NTTADEKDPT NPFRFPNIGV EKFLELNSEQ NHDDYCLAYV FTDRDFDDGV LGLAWVGAPS GSSGGICEKS KLYSDGKKKS LNTGIITVQN YGSHVPPKVS HITFAHEVGH NFGSPHDSGT ECTPGESKNL GQKENGNYIM YARATSGDKL NNNKFS
Proinflammatory cytokine tumor necrosis factor-a (TNF-a) contributes to a variety of inflammatory responses and programmed cell death. Notch receptor and its ligand participate in cell fate decisions during vertebrate development and are associated with several human disorders, including a T-cell lymphoma. TNF-a, notch and its ligand delta are all membrane-bond molecules, which are cleaved by proteases to release mature proteins or functional receptor. ADAM10, a metalloprotease-disintegrin in the family of mammalian ADAM (for a disintegrin and metalloprotease), was recently identified to cleave TNF-a, notch and its ligand delta (1-3). The genes encoding human, mouse, and bovine ADAM10 were recently cloned and designated ADAM 10, kuzbanian (KUZ), and MADM, respectively. ADAM10 mRNA is expressed in a variety of human and bovine tissues.Specifications
| ADAM10 | |
| Polyclonal | |
| Unconjugated | |
| Adam10 | |
| 1700031C13Rik, a disintegrin and metallopeptidase domain 10, a disintegrin and metalloprotease domain (ADAM) 10, a disintegrin and metalloprotease domain 10, a disintegrin and metalloproteinase, AD10, AD18, ADAM, ADAM 10, ADAM metallopeptidase domain 10, ADAM10, ADAMs, CD156c, CDw156, Disintegrin and metalloproteinase domain-containing protein 10, HsT18717, KUZ, kuzbanian, kuzbanian protein homolog, MADM, Mammalian disintegrin-metalloprotease, metalloendopeptidases, metalloproteinase, myelin-associated metalloproteinase, RAK | |
| Rabbit | |
| Affinity Chromatography | |
| RUO | |
| 102, 11487 | |
| -20° C, Avoid Freeze/Thaw Cycles | |
| Liquid |
| Immunocytochemistry, Western Blot | |
| 0.62 mg/mL | |
| PBS with 50% glycerol and 0.05% ProClin 300, pH 7.3 | |
| O14672, O35598 | |
| Adam10 | |
| Recombinant fusion protein containing a sequence corresponding to amino acids 218-433 of human ADAM10 (NP_0011011) | |
| 100 μL | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |