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  5. Tocris Bioscience™ AC 710

Tocris Bioscience™ AC 710
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Product Code. p-5545516
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Quantity:
10 mg
50 mg
Unit Size:
10mg
50mg
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Product Code. 18720278

Brand: Tocris Bioscience™ 5013/10

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Description

Potent and selective PDGFR family inhibitor

AC 710 is a potent PDGFR family inhibitor (IC50 values are 1.2, 2, 7.7 and 10.5 nM for KIT, FLT3, PDGFRβ and CSF1R respectively; Kd = 1.3 nM for PDGFRα). Exhibits >30-fold selectivity over a panel of other kinases and exhibits no activity against cytochrome P450. Causes tumor regression of leukemia cell xenografts in mice. Also reduces joint swelling and inflammation in a mouse model of collagen-induced arthritis. Orally active.
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Specifications

Quantity 10 mg
Product Type AC 710
Purity >99%
Molecular Weight (g/mol) 562.7

For Research Use Only

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