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Fasudil, 98+%, Thermo Scientific™

Brand:  Thermo Scientific Alfa Aesar J63525.MA

Quantity 10mg

Product Code. 15415739

  • 322.00€ / 10mg

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Description

Description

This Thermo Scientific brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific.

Applications
HA-1077 dihydrochloride has been shown to be a vasodilating agent as well as a potent inhibitor of Rock-2 (Rho-associated Kinase II), cGKI (cGMP-dependent protein kinase), PKA (cAMP-dependent protein kinase), MYLK, and CaMKII. Rho kinase signaling pathways are thought to cause invasion, migration, and proliferation of certain cells. Studies have shown this compound can also inhibit myosin light chain kinase in vitro and suppress cell rounding by myosin light chain phosphorylation. Mechanistic experiments report that HA-1077 inhibits vascular smooth muscle contraction by acting as a calcium channel protein inhibitor. HA-1077 dihydrochloride is an inhibitor of MSK1, PKC, PRK2 and Rsk-2.

Solubility
Soluble in water or DMSO

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from oxidizing agents.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

103745-39-7
MFCD00866182
14,3942
Soluble in water or DMSO
C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CN=C3
291.369
327.83
Fasudil
C14H17N3O2S
10mg
fasudil, fasudil inn, 5-1,4-diazepane-1-sulfonyl isoquinoline, fasudilum inn-latin, 1-5-isoquinolinesulfonyl homopiperazine, unii-q0ch43pgxs, 1h-1,4-diazepine, hexahydro-1-5-isoquinolinylsulfonyl, 5-1,4-diazepan-1-ylsulfonyl isoquinoline, 5-isoquinolinesulfonyl homopiperazine, q0ch43pgxs
NGOGFTYYXHNFQH-UHFFFAOYSA-N
5-(1,4-diazepan-1-ylsulfonyl)isoquinoline
3547
≥98%
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