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6-Azauridine

Product Code. 15453919
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Product Code. 15453919 Supplier Thermo Scientific Alfa Aesar Supplier No. J61309.03
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Description

CAS: 54-25-1 | C8H11N3O6 | 245.191 g/mol

6-Azauridine can be applied in antiviral studies. 6-azauridine inhibits de novo pyrimidine synthesis and DNA synthesis and is converted intracellularly into mono, di, and triphosphate derivatives, which incorporate into RNA and inhibit protein synthesis. It is also used as an antineoplastic antimetabolite. It interferes with pyrimidine biosynthesis thereby preventing formation of cellular nucleic acids. As the triacetate, it is also effective as an antipsoriatic.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
6-Azauridine can be applied in antiviral studies. 6-azauridine inhibits de novo pyrimidine synthesis and DNA synthesis and is converted intracellularly into mono, di, and triphosphate derivatives, which incorporate into RNA and inhibit protein synthesis. It is also used as an antineoplastic antimetabolite. It interferes with pyrimidine biosynthesis thereby preventing formation of cellular nucleic acids. As the triacetate, it is also effective as an antipsoriatic.

Solubility
It is soluble in water.

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2 - 8°C
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 54-25-1
Molecular Formula C8H11N3O6
Molecular Weight (g/mol) 245.191
MDL Number MFCD00006472
InChI Key WYXSYVWAUAUWLD-SHUUEZRQSA-N
Synonym 6-azauridine, 6-azuridine, azauridine, azur, riboazauracil, riboazauratsil, 6-azauracil 1-riboside, ribo-azuracil, 6-azauracil riboside, 6-azur
PubChem CID 5901
ChEBI CHEBI:35668
IUPAC Name 2-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazine-3,5-dione
SMILES C1=NN(C(=O)NC1=O)C2C(C(C(O2)CO)O)O

Specifications

Melting Point 160°C to 161°C
Color White
Quantity 1 g
Merck Index 14,904
Solubility Information It is soluble in water.
Formula Weight 245.19
Physical Form Powder
Chemical Name or Material 6-Azauridine

Safety and Handling

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Product Identifier
  • 6-Azauridine
 Signal Word
  • Warning
 Hazard Category
  • Acute toxicity Category 4
  • Carcinogenicity Category 2
 Hazard Statement
  • H302-Harmful if swallowed.
  • H312-Harmful in contact with skin.
  • H332-Harmful if inhaled.
  • H351-Suspected of causing cancer.
 Precautionary Statement
  • P280-Wear protective gloves/protective clothing/eye protection/face protection.
  • P301+P330+P331-IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
  • P302+P352-IF ON SKIN: Wash with plenty of water/soap.
  • P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
  • P312-Call a POISON CENTER/doctor/if you feel unwell.
 Supplemental information
  • MIXTURE LIST-Contains : 6-Azauridine
SDS

RUO – Research Use Only

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