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5-Iodotubercidin, Tocris Bioscience™
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Quantity:
1 mg
Description
Potent adenosine kinase inhibitor (IC50 = 26 nM). Also nucleoside transporter inhibitor (IC50 values are < 25 nM, 7 μM and 15 μM for inhibition of [3H]adenosine, [3H]uridine and [3H]formycin B uptake respectively). Strongly stimulates glycogen synthesis in hepatocytes via activation of glycogen synthase. Also inhibits CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2 and PKC (IC50 values are 0.4, 3.5, 5-10, 5-10, 10.9 and 27.7 μM respectively). Decreases hippocampal DNA methylation through adenosine kinase inhibition in vivo.
Specifications
| CAS | 24386-93-4 |
| Molecular Formula | C11H13IN4O4 |
| MDL Number | MFCD00055131 |
| Quantity | 1 mg |
| Synonym | 5-iodotubercidin, 5-iodotubericidin, 7-iodo-7-deazaadenosine, 7-iodotubercidin, 2r,3r,4s,5r-2-4-amino-5-iodo-7h-pyrrolo 2,3-d pyrimidin-7-yl-5-hydroxymethyl tetrahydrofuran-3,4-diol, 7-deaza-7-iodoadenosine, chembl99203, 7h-pyrrolo 2,3-d pyrimidin-4-amine,5-iodo-7-b-d-ribofuranosyl, 5-iodo-7-beta-d-ribofuranosyl-7h-pyrrolo 2,3-d pyrimidin-4-amine |
| InChI Key | WHSIXKUPQCKWBY-UHFFFAOYNA-N |
| SMILES | NC1=C2C(I)=CN(C3OC(CO)C(O)C3O)C2=NC=N1 |
| IUPAC Name | 2-{4-amino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl}-5-(hydroxymethyl)oxolane-3,4-diol |
| Molecular Weight (g/mol) | 392.15 |
| PubChem CID | 97297 |
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