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DiscoverX Ready-to-Assay™ A2A Adenosine Receptor Frozen Cells

Product Code. 17315069
Encompass
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Quantity:
2 Vials of Cells
Unit Size:
2 ampoules
This item is not returnable. View return policy

Product Code. 17315069

Brand: DiscoverX HTS048LRTA

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This item is not returnable. View return policy

Description

The Ready-to-Assay™ A2A Adenosine Receptor Frozen Cells measure ADORA2A (GPCR) activation via an increase in intracellular calcium. Ready-to-Assay kits contain two vials of thaw-and-use cells.

The Ready-to-Assay™ A2A Adenosine Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. adenosine, NECA) based activation of ADORA2A GPCR activity via detection of increasing levels of intracellular calcium. The included cells overexpress ADORA2A alongside exogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. ChemiBrite cells also express a clytin variant, allowing for luminescent as well as fluorescent signal detection. Upon activation of ADORA2A , the resulting calcium activity can be assayed in either detection mode. Ready-to-assay kits consist of two vials of the cells in a convenient thaw-and-use format.

Specifications

Assay Entry A2A
For Use With (Application) Frozen Cells
Primary Agonist adenosine, NECA
Quantity 2 Vials of Cells
Target Entry ADORA2A
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